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COVID, Quickly, Episode 13: Vaccine Approval, Breakthrough Infections, Boosters

by Scientific American
August 27th 2021
Today we bring you a new episode in our podcast series COVID, Quickly. Every two weeks, Scientific American ’s senior health editors Tanya Lewis and Josh Fischman catch you up on the essent... More
You decided to upgrade your outdoor deck. So you ordered the essentials, a power washer, a set of patio chairs and a shiny new grill and you use your bank of America customized cash rewards. Credit card choosing to earn 3% cash back on online shopping and up to 5.25% as a preferred rewards member. Which you put towards your most essential death edition, A bird feeder apply for yours at bank of America dot com slash more rewarding. Copyright 2021 Bank of America Corporation. Hi and welcome to Covid. Quickly a scientific american podcast series. This is your fast track update to the covid pandemic. We bring you up to speed on the science behind the most urgent questions about the virus and the disease. We demystify the research and help you understand what it really means. I'm Tonya. Lewis, I'm josh Fishman and were scientific american's senior health editors. Today we're going to talk about the FDA approval of the Pfizer vaccine.

Whether new reports of breakthrough infections mean vaccines are losing power and what you need to know about vaccine booster shots. This week, the food and drug administration granted full approval to the Pfizer vaccine for people ages 16 and older. That moves the shot past its initial emergency use status and makes it like any approved drug or vaccine. Will this solid endorsement affect vaccination rates. Tanya, it could affect them in a couple of ways. A growing number of government agencies, cities and businesses have already started implementing vaccine mandates for example the U. S. Military instituted a mandate for all active duty service members. New york city is requiring all department of education teachers and staff to get vaccinated and lots of colleges and universities are implementing mandates to the other. Big question is whether the FDA approval will sway any people who are vaccine hesitant on that front. It may be a big uphill battle. While some people say that the lack of FDA approval was their main reason for not getting vaccinated. Others cite mistrust of government and other concerns which are not likely to magically disappear.

Now that the FDA has given it its formal stamp of approval time will tell if the approval will have a big impact on vaccination rates. Right now though the delta variants rapid spread is what appears to be driving an increase in vaccinations. In many of the hardest hit states. We keep hearing more about breakthrough infections. When the virus infects people who are fully vaccinated, that doesn't mean the vaccines don't work anymore though. Right josh. The vaccines still work really well. Tanya and we have some new numbers to back that up. There have been headlines about prominent people who tested positive even though they were vaccinated three U. S. Senators last week for example and when these stories appear in such a cluster, it gives the impression that vaccines are losing protective power. The real story however is different. These vaccines never gave perfect protection. Even in clinical trials. For instance, Pfizer reported eight vaccinated people got infected out of about 20,000 people who got the shots. But 162 people in the unvaccinated trial group got the disease.

And that's a lot more With the highly transmissible delta variant. That's dominating new cases. Now these numbers have changed a bit but the pattern of good vaccine protection still holds this week, the CDC reported on 43,000 infections in Los Angeles County between May and the end of July, about 70% of them were an unvaccinated people. About 25% were in fully vaccinated folks. So while that's more infections than we saw in the clinical trials, vaccinated people were still almost three times more likely to repel the virus than were people without the vaccine. When it came to people who got sick enough to need a hospital and intensive care. The power of the vaccines was clear. 7.5% of the unvaccinated had to be hospitalized. That was true of about 3% of the vaccinated people. So the vaccines are twice as likely to keep you out of the hospital and hold the virus to just a mild illness Oregon just reported on its covid infections in july 81% were an unvaccinated people.

So that makes 19% of them and breakthrough cases. Again a big advantage for vaccines. That's also true for the most serious consequences of covid, 45 deaths wherein people who did not get vaccinated. The US has now vaccinated nearly 172 million people. The virus has now spread much more widely through the country. Both of these trends are going to run into one another more often. And that means more vaccinated people will get infected. But clearly a lot fewer of them will get the virus than unvaccinated people. Even more clearly the vaccine will keep the huge majority of them from getting seriously ill. And really that's what any vaccine is supposed to do. The big debate now is about Covid booster shots. The biden administration said it plans to offer boosters to all eligible americans eight months after their second shot of an MRNA vaccine. Are these needed and needed by whom those are important questions and we don't have all the answers yet. What we do know is that some data from Israel as well as the CDC's own studies in the US suggest that vaccinated people may be more susceptible to mild or moderate infections now than previously.

This may be the result of waning immunity over time. The effect of the delta variant or some combination of the two. The good news though is that the vaccines still appear to provide excellent protection against severe disease and death. As you mentioned, the vast majority of people hospitalized for Covid right now are unvaccinated. As for who needs boosters. I spoke with some experts for a story earlier this week including Celine gounder of N. Y. U. And Shane Crotty of the La Hoya Institute of immunology. They said it was clear that people who are immunocompromised or the very elderly, especially those living in nursing homes may benefit from an additional dose of vaccines. But there's not much evidence yet that healthy people will need to boost her anytime soon. Both Gounder and Crotty agreed that the bigger focus right now should be on getting unvaccinated people their 1st and 2nd shots. Because the benefits of doing so far outweigh the benefits of giving a subset of people booster shots, vaccinating the rest of the country and the world is really the key to ending this pandemic. Now you're up to speed. Thanks for joining us. Come back in two weeks for the next episode of Covid quickly and check out siam dot com for updated and in depth Covid news.

Mm Yeah.

COVID, Quickly, Episode 13: Vaccine Approval, Breakthrough Infections, Boosters
COVID, Quickly, Episode 13: Vaccine Approval, Breakthrough Infections, Boosters
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